PTEN profiling
نویسندگان
چکیده
منابع مشابه
Pharmacogenomic Profiling of the PI3K/PTEN Pathway in Sporadic Breast Cancer
Background: Pharmacogenomics is the study of genetic variations among individuals to predict the probability that a patient will respond to single or multidrug chemotherapy. Breast cancer is one of the most common cancers among women worldwide. Treatment of breast cancer by application of biological rationales gives us the ability to match the correct pharmacology to individual tumour genetic p...
متن کاملpharmacogenomic profiling of the pi3k/pten pathway in sporadic breast cancer
background: pharmacogenomics is the study of genetic variations among individuals to predict the probability that a patient will respond to single or multidrug chemotherapy. breast cancer is one of the most common cancers among women worldwide. treatment of breast cancer by application of biological rationales gives us the ability to match the correct pharmacology to individual tumour genetic p...
متن کاملPten
What does it look like? PTEN looks just like a tyrosine phosphatase, an exciting discovery as many tumors are caused by too much tyrosine kinase activity. However, it dephosphorylates tyrosine-phosphorylated proteins only very poorly although a couple of putative subtrates have been identified. But in 1998, Jack Dixon’s group showed that PTEN could dephosphorylate a particular phospholipid, pho...
متن کاملPten
PTEN (phosphatase and tensin homolog on chromosome ten) is a dual protein/lipid phosphatase that dephosphorylates PIP3, thereby inhibiting the AKT/mTOR pathway. This inhibition ultimately decreases protein translation, cell proliferation and cell growth. In the central nervous system, inhibition of PTEN leads to increased stem cell proliferation, somatic, dendritic and axonal growth, accelerate...
متن کاملPharmacogenomic profiling of the PI3K/PTEN pathway in sporadic breast cancer.
BACKGROUND Pharmacogenomics is the study of genetic variations among individuals to predict the probability that a patient will respond to single or multidrug chemotherapy. Breast cancer is one of the most common cancers among women worldwide. Treatment of breast cancer by application of biological rationales gives us the ability to match the correct pharmacology to individual tumour genetic pr...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2001
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20011107-01